9/17/2023 0 Comments Aging zebrafish circuliCardiovascular diseases are the leading cause of death, representing 32% of all deaths globally in 2019 (World Health Organization- (accessed on 3 September 2021)). Organ failure and degenerative diseases thus have a major impact on human health, especially when we age. The ability to replace missing or damaged tissue, organs or even entire body parts and functionally integrate these regenerates into the existing structures is limited to a few organs, including the liver, intestine, skeletal muscle and the hematopoietic system. The gradual decline of tissue functionality is the main reason humans suffer from age-related diseases. Taken together, these data indicate an ‘inflammaging’-like process in the zebrafish heart and suggest a change in regenerative response in the old. Collagen in the wound area was already significantly enriched in old fish at 7 days post injury. Our data further suggest that the regenerative response to cardiac injury is generally impaired and much more variable in old fish. Those immune cells not only increased in numbers but also showed morphological and behavioral changes with age. Our data show an accumulation of immune cells, mostly macrophages, in the old zebrafish ventricle. We identified the immune system as activated in old ventricles and found muscle organization to deteriorate upon aging. Here, we have compared the ventricular transcriptome as well as the regenerative capacity after cryoinjury of old and young zebrafish hearts. In addition, zebrafish has recently become a model organism in research on aging. In contrast to humans, zebrafish have extraordinary regeneration capacities of complex organs including the heart. Cardiovascular dysfunction has an increasing prevalence with age and is one of the leading causes of death. Age-associated organ failure and degenerative diseases have a major impact on human health.
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